Proteínas de novo: del diseño a la funcionalización
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El diseño de proteínas de novo es un campo innovador con aplicaciones relevantes en medicina y biotecnología. Consiste en crear proteínas “desde cero”, con secuencias de aminoácidos completamente distintas a las presentes en la naturaleza. Este trabajo presenta la evolución del campo, desde sus inicios con el diseño minimalista y racional en los años ochenta, hasta el uso de modelos de lenguaje basados en aprendizaje profundo. El objetivo principal es ofrecer a estudiantes de licenciatura y posgrado un panorama general sobre los avances en el diseño de proteínas de novo y su vínculo con el plegamiento y la funcionalidad proteica.
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