Chemotherapy-induced oral stomatotoxicity

Abstract

The principal aim of the present study was to determine the type of oral lesions most frequently found in breast cancer patients treated with chemotherapy at the General Hospital in Mexico City and establish under which circumstances these manifestations occur. A fi le review was undertaken, spanning from 1994 to 1999. Inclusion and exclusion criteria were established. Out of 405 cases under consideration, 327 cases were included in the sample. In these selected cases, stomatotoxicity was present in 129 cases: 89 cases exhibited only a single oral manifestation, 19 cases showed two and 14 cases exhibited more than two (three or more). Relationship between histological lineage was reflected; it was present in the infi ltrating ducts, lobular and others (p < .005). Treatment schemes with chemotherapy were integrated with 5-fl uorouracil, adriamycin, cyclophosphamide and methrotrexate (p < .005) dosage and stomatotoxicity were related (p < .005).