Energetic metabolism and cancer

Abstract

One of the most important characteristics of many types of cancer is the presence of an abnormal metabolism such as enhanced glucose uptake and glycolysis and decreased oxidative metabolism. The regulation of energy metabolism is complex, some regulatory proteins, like HIF (pro-metastatic protein), decrease oxidative metabolism, whereas other proteins, like p53 (tumor suppressor), promote oxidative phosphorylation. These data indicate that one of the possible primary roles of activated oncogenes and inactivated tumor suppressors is the reprogramming of cell metabolism.